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B12 is involved in processes that support mood regulation

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You had people suffering from anemia, and suddenly they were healed. Heber remembers being at a hospital in Bishop, California, when a wheelchair-bound man who had undergone gastric bypass surgery came in complaining of fatigue

In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )